Article Text
PDFCase report
Pneumocystis jirovecii pneumonia as a complication of etoposide therapy
Abstract
Two patients receiving oral etoposide therapy developed Pneumocystis jirovecii pneumonia during chemotherapy with significant lymphopenia without corticosteroid use. In this commentary we discuss cellular mechanisms by which etoposide induced CD4+ T lymphocyte dysfunction and reduced survival may lead to predisposition to P. jirovecii infection.
- malignant disease and immunosuppression
- infections
- haematology (incl blood transfusion)
- pneumonia (infectious disease)