Differential diagnosis of lower limbs swelling
| Lymphoedema | Vascular malformation | Lipoedema | Tumour | |
| Onset | Infancy/adolescence | Infancy | Adolescence | Infancy |
| Familial transmission | ± | – | ± | – |
| Laterality | Unilateral/bilateral | Unilateral | Bilateral | Unilateral |
| Foot/hand involvement | + | ± | – | ± |
| Cutaneous involvement | ± | + | – | + |
| Aberrant blood tests | – | ± | – | ± |
| Lymphoscintigraphy | + | – | – | – |
| MRI findings | Increasing subcutaneous adipose/oedema | Aberrant blood vessels | Increasing subcutaneous adipose | Tumour-specific (increasing lesion) |