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Reminder of important clinical lesson
CASE REPORT
Myoclonic status epilepticus induced by cefepime overdose requiring haemodialysis
  1. Aude Garin and
  2. Florent Bavozet
  1. Department of Intensive Care, Centre Hospitalier Victor Jousselin, Dreux, France
  1. Correspondence to Dr Aude Garin, agarin{at}ch-dreux.fr

Abstract

We report a case of cefepime neurotoxicity characterised by myoclonic status epilepticus with coma, in a context of acute renal failure and requiring one discontinuous conventional haemodialysis. Cefepime is a fourth-generation broad‐spectrum cephalosporin mainly used to treat hospital-acquired Gram-negative infections. Acute neurotoxicity is an increasingly reported adverse effect which occurs predominantly in patients with renal impairment. Renal replacement therapy has been proposed to treat this condition.

  • healthcare improvement and patient safety
  • epilepsy and seizures
  • unwanted effects/adverse reactions
  • dialysis

https://doi.org/10.1136/bcr-2018-228108

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    Footnotes

    • Contributors AG and FB served as study coordinators, as well as provided and cared for study patient. Both authors read and approved the final manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Patient consent for publication Not required.