You are here

Article Text

Article menu
Download PDFPDF
Case Reports: Adverse drug reactions and complications
Case of reactive sacroiliitis possibly induced by an mRNA coronavirus disease vaccine
  1. Nicolas Roux1,
  2. Sophie Poussing2 and
  3. François Maurier3
  1. 1Rheumatology Department, UNEOS Hôpitaux Privés de Metz, Metz-Vantoux, Lorraine, France
  2. 2Biological Laboratory, UNEOS Hopitaux Prives de Metz, Metz, Lorraine, France
  3. 3Internal Medicine and Clinical Immunology Department, UNEOS Hopitaux Prives de Metz, Metz-Vantoux, Lorraine, France
  1. Correspondence to Dr François Maurier; francois.maurier{at}uneos.fr

Abstract

A woman in her 30s received a second dose, first booster, Corminaty vaccine against the SARS-CoV-2. Three days later, the patient developed unilateral sacroiliitis. A pelvic scan revealed inflammatory joint edges, bone erosion and a heterogeneous mass of 2.5 cm in the psoas muscle. Joint puncture revealed no microcrystalline deposits, but bone marrow cells, erythroblast were identified. The standard bacterial cultures and culture for mycobacteria were negative. HLA B27 was negative, and no seroconversion was identified for HIV, Epstein-Barr virus, cytomegalovirus, chlamydia or Quantiferon. Two months later, the sacroiliitis resolved.

The aetiologic approach of this erosive unilateral acute sacroiliitis in a person naïve to rheumatologic pathology was negative for inflammatory or infectious sacroiliitis. Arthralgias after vaccination are expected. Arthritis is less common, and acute sacroiliitis has not yet been described. Acute sacroiliitis may be considered a reactive sacroiliitis to the anti-COVID-19 mRNA vaccine.

  • Immunological products and vaccines
  • Vaccination/immunisation
  • Anklosing spondylitis
  • COVID-19
  • Healthcare improvement and patient safety

https://doi.org/10.1136/bcr-2022-249063

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors All the authors and co-authors participated to the care of the patient. All analysed and interpreted data, wrote the paper equally to the final approval of the version proposed to BMJ Case Report. NR specifically worked on the radiological images, SP particularly worked on biological data and FM worked on conception, design, analysis and interpretation of data for the draft.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.