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Fetus in fetu: the importance of autopsy in uncovering hidden abnormalities
  1. Umamaheswari Gurusamy1,
  2. Vartika Goel1 and
  3. Shyama Devadasan2
  1. 1Pathology, PSG Institute of Medical Sciences and Research, Coimbatore, TamilNadu, India
  2. 2Obstetrics and Gynecology, Ambady Fetal and Maternal Care Centre, Thrissur, Kerala, India
  1. Correspondence to Dr Vartika Goel; vgoel1992{at}gmail.com

Abstract

Fetus in fetu (FIF) is a rare anomaly of embryogenesis in which a malformed parasitic twin is found within the body of the normally developed host twin. It has a reported incidence of 1 per 500 000 births with a 2:1 male predominance. The authors present a unique case of FIF, where autopsy investigation played a pivotal role in identifying this exceptionally rare anomaly, rarely documented in the literature. A primigravida woman in her early 20s was diagnosed with FIF at 13+3 weeks of gestation. She opted for medical termination of her pregnancy. The postmortem examination confirmed the diagnosis of FIF. Malformations in both fetuses, namely, partial urorectal septum malformation in the parasitic twin and heterotaxy syndrome in the host twin, were unmasked by fetal autopsy.

The significance of autopsy examination in FIF cases is underscored by our case, as it facilitates the diagnosis of this rare entity and the reporting of congenital anomalies in the aforementioned.

  • Pathology
  • Ultrasonography
  • Materno-fetal medicine
  • Congenital disorders
  • Genetics

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Footnotes

  • Contributors UG and VG were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms and critical revision for important intellectual content: UG. VG gave final approval of the manuscript. We express our gratitude to SD fetal medicine specialist for referring this case to us for autopsy examination. UG is the guarantor of the content of this article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.