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Gastroenterology
Gastrointestinal involvement in metastatic melanoma
  1. Shreya Chahure1,
  2. Juan De La Revilla Negro1,
  3. Mohmmed Sharip1 and
  4. James Chan2
  1. 1Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  2. 2Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  1. Correspondence to Dr Shreya Chahure; schahure{at}gmail.com

Abstract

This case report details two instances of gastrointestinal (GI) involvement in metastatic melanoma. The first patient, a man in his mid-70s with a history of melanoma and recent brain metastases, presented with melaena and was found to have metastatic lesions in the stomach and duodenum. The second patient, a man in his late 50s with a history of chest wall melanoma, presented with complex GI symptoms and was discovered to have a metastatic melanoma lesion at the gastro-oesophageal junction. Both cases highlight the importance of maintaining a high degree of suspicion for GI metastasis from melanoma in patients presenting with GI symptoms, emphasising timely endoscopic evaluation and biopsy for accurate diagnosis and management.

  • Gastroenterology
  • Endoscopy
  • GI bleeding
  • Skin cancer
  • Stomach and duodenum

https://doi.org/10.1136/bcr-2024-262631

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    Footnotes

    • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms and critical revision for important intellectual content: JDLRN, MS, SC and JC. The following authors gave final approval of the manuscript: JDLRN, MS, SC and JC. Is the patient one of the authors of this manuscript? No. The guarantor is JDLRN.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.