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Obstetrics and gynaecology
Ovarian hyperstimulation syndrome in a patient on tamoxifen therapy
  1. Ashley M Olmsted and
  2. Jonathan Thomas Hunt
  1. Obstetrics and Gynecology, Naval Medical Center Portsmouth, Portsmouth, Virginia, USA
  1. Correspondence to Dr Jonathan Thomas Hunt; jonathan.t.hunt.mil{at}health.mil

Abstract

Ovarian hyperstimulation syndrome (OHSS) in patients on tamoxifen therapy is a rare but potentially serious complication. This patient underwent a laparoscopic unilateral salpingo-oophorectomy due to persistent pelvic pain and received a gonadotropin-releasing hormone (GnRH) agonist injection with normalisation of her oestradiol level, previously elevated to 956 pg/mL. Management options of OHSS include medical therapy with GnRH agonists or surgical intervention. Studies have shown that GnRH agonists can effectively normalise oestradiol levels and induce the resolution of cysts in these patients. Additionally, combined therapy with tamoxifen and GnRH agonists may reduce the risk of OHSS. Risk factors for OHSS during tamoxifen treatment include younger age and absence of chemotherapy. Monitoring of oestradiol levels and close clinical follow-up are essential in managing patients on tamoxifen therapy to prevent and promptly address OHSS.

  • Drugs: obstetrics and gynaecology
  • Obstetrics, gynaecology and fertility

https://doi.org/10.1136/bcr-2024-264549

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    Footnotes

    • Contributors AMO and JTH were directly involved in the patient’s care. JTH is the clinician in charge of the clinical care of the patient, supervised the preparation of the manuscript, was responsible for obtaining informed consent from the patient/guardian/family members and was responsible for the overall integrity of the content of the manuscript as the guarantor.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Disclaimer AMO and JTH are military service members. This work was prepared as part of their official duties. Title 17 U.S.C. 105 provides that “Copyright protection under this title is not available for any work of the United States Government.” Title 17 U.S.C. 101 defines a United States Government work as a work prepared by a military service member or employee of the United States Government as part of that person’s official duties. The views expressed in this article reflect the results of research conducted by the author(s) and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the United States Government.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.